INTRAUTERINE GROWTH RESTRICTION IN PREGNANCY-INDUCED HYPERTENSION: INCIDENCE AND ASSOCIATED FACTORS IN A TERTIARY CARE SETTING OF KHYBER PAKHTUNKHWA, PAKISTAN
DOI:
https://doi.org/10.66604/cevqgz95Keywords:
pregnancy-induced hypertension, intrauterine growth restriction , gestational age , parity, weightAbstract
Background: Pregnancy-induced hypertension (PIH) is one of the leading risk factors, commencing greater foetal and maternal morbidity and mortality worldwide. Among other complications, intrauterine growth restriction (IUGR) is a significant outcome of PIH. In the Pakistani context, the incidence of IUGR in PIH women and comparison with human factors is rarely determined. This study aimed to find the frequencies of IUGR among PIH women presenting to a tertiary care setup and determine the possible effect of age, gestation age, parity, and weight on IUGR. Methods: This cross-sectional study was conducted from 1st March to 30th August 2023 at the Department of Obstetrics and Gynaecology, Ayub Teaching Hospital, Abbottabad. The research comprised 159 pregnant women who had hypertension problems. The researcher underlined that all women underwent ultrasound biometry to determine IUGR per the Royal College of Obstetricians and Gynaecologists criteria. Results: Among the total 159 PIH women with a mean age of 27.691±2.63 years, the incidence of IUGR is 10.7%. IUGR was more prevalent in the 31–40 age group, i.e., 13%, having gestational age more than 30 weeks, i.e.16%, parity, i.e. 9.8%, and weight more than 70kg, i.e. 45.7%. Conclusion: The incidence of IUGR among women with PIH is low compared to neighbouring developing countries and requires individualized perinatal care, particularly among older aged, overweight, nulliparous, and beyond 30 weeks of gestation on a priority basis.
References
Luger RK, Kight BP. Hypertension in pregnancy. 2022 Oct. In: StatPearl [Internet] 2025. Treasure Island (FL): StatPearls Publishing; 2025.
Agarwal GS, Agrawal AK, Singhal D, Bawiskar D, Shedge SS. Pregnancy-induced hypertension pathophysiology and contemporary management strategies: A narrative review. Cureus 2024;16(7):e63961. DOI: https://doi.org/10.1002/hsr2.1274 DOI: https://doi.org/10.7759/cureus.63961
Dapkekar P, Bhalerao A, Kawathalkar A, Vijay N. Risk factors associated with intrauterine growth restriction: A case-control study. Cureus 2023;15(6):e40178. DOI: https://doi.org/10.7759/cureus.40178 DOI: https://doi.org/10.7759/cureus.40178
Dinu M, Stancioi-Cismaru AF, Gheonea M, Luciu ED, Aron RM, Pana RC, et al. Intrauterine growth restriction-prediction and peripartum data on hospital care. Medicina (Kaunas) 2023;59(4):773. DOI: https://doi.org/10.3390/medicina59040773. DOI: https://doi.org/10.3390/medicina59040773
Gordijn SJ, Beune IM, Thilaganathan B, Papageorghiou A, Baschat AA, Baker PN, et al. Consensus definition of foetal growth restriction: A Delphi procedure. Ultrasound Obstet. Gynecol. 2016;48:333–339.DOI: https://doi.org/10.1002/uog.15884. DOI: https://doi.org/10.1002/uog.15884
Calek E, Binder J, Palmrich P, Eibensteiner F, Thajer A, Kainz T, et al. Effects of intrauterine growth restriction (IUGR) on growth and body composition compared to constitutionally small infants. Nutrients 2023;15(19):4158. DOI: https://doi.org/10.3390/nu15194158 DOI: https://doi.org/10.3390/nu15194158
Jabeen SS, Raoof M, Mumtaz F, Khan B, Shaheen Z. Intrauterine growth restriction among pregnant hypertensive women of urban and rural areas. Pak J Med Dent 2023;12(3):29–35. DOI: https://doi.org/10.36283/PJMD12-3/006 DOI: https://doi.org/10.36283/PJMD12-3/006
Barros FC, Barros AJ, Villar J, Matijasevich A, Domingues MR, Victora CG. How many low birthweight babies in low-and middle-income countries are pre-term? Rev Saude Publica 2011;45(3):607–16. DOI: https://doi.org/10.1590/S0034-89102011005000019 DOI: https://doi.org/10.1590/S0034-89102011005000019
El-Baz MA, El-Deeb TS, El-Noweihi AM, Mohany KM, Shaaban OM, Abbas AM.. Environmental factors and apoptotic indices in patients with intrauterine growth retardation: a nested case-control study. Environ Toxicol Pharmacol 2015;39(2):589–96. DOI: https://doi.org/10.1016/j.etap.2015.01.009 DOI: https://doi.org/10.1016/j.etap.2015.01.009
Zafar H, Naz M, Fatima U, Irshad F. Frequency of IUGR in pregnancy induced hypertension. J Uni Med Dent Coll 2012;3(2):8–13.
Fox NS, Saltzman DH, Oppal S. The relationship between pre-eclampsia and intrauterine growth restriction in twin pregnancies. Am J Obstet Gynecol 2014;211(4):422.e1–5. DOI: https://doi.org/10.1016/j.ajog.2014.05.035
Almuhaytib FA, AlKishi NA, Alyousif ZM. Early Onset pre-eclampsia and intrauterine growth restriction: A case report. Cureus 2023;15(1):e33919. DOI: https://doi.org/10.7759/cureus.33919 DOI: https://doi.org/10.7759/cureus.33919
Gudeta TA, Regassa TM. Pregnancy induced hypertension and associated factors among women attending delivery service at Mizan-Tepi University Teaching Hospital, Tepi General Hospital and Gebretsadik Shawo Hospital, Southwest, Ethiopia. Ethiop J Health Sci 2019;29(1):831–40. DOI: https://doi.org/10.4314/ejhs.v29i1.4 DOI: https://doi.org/10.4314/ejhs.v29i1.4
Majeed S, Khawaja A, Tunio NA, Unar F, Khan FA. To determine frequency of intrauterine growth restriction in pregnancy induced hypertension. Pak J Med Health Sci 2020;14(2):240–2.
Febrina NAD, Primadi A, Lestari BW. Association between intrauterine growth restriction and pregnancy hypertension. Althea Med J 2016;3(2):212–5. DOI: https://doi.org/10.1186/s12889-019-7973-9 DOI: https://doi.org/10.15850/amj.v3n2.791
Dumolt JH, Powell TL, Jansson T. placental function and the development of foetal overgrowth and foetal growth restriction. Obstet Gynecol Clin North Am 2021;48(2):247–66. DOI: https://doi.org/10.1016/j.ogc.2021.02.001 DOI: https://doi.org/10.1016/j.ogc.2021.02.001
Napso T, Lean SC, Lu M, Mort EJ, Desforges M, Moghimi A, et al. Diet-induced maternal obesity impacts feto-placental growth and induces sex-specific alterations in placental morphology, mitochondrial bioenergetics, dynamics, lipid metabolism and oxidative stress in mice. Acta Physiol (Oxf) 2022;234(4):e13795. DOI: https://doi.org/10.1111/apha.13795 DOI: https://doi.org/10.1111/apha.13795
Qamar MK, Khan YQ, Irum N, Manzppr S. Frequency of intrauterine growth retardation in obese pregnant females: A cross sectional study in two tertiary care hospitals of Pakistan. J Soc Obstet Gynaecol Pak 2021;11(4):246–9.
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