SUCCESSFUL INDUCTION OF LABOUR WITH DINOPROSTONE IN BEYOND 36 WEEKS OF  PREGNANCIES: AN OBSERVATIONAL STUDY

Induction of labour with dinoprostone

Authors

  • Komal Imtiaz King Abdullah Teaching Hospital Mansehra, Health Department KPK Author
  • Qurat Ul Aim King Abdullah Teaching Hospital Mansehra, Health Department KPK Author
  • Maria Nawaz King Abdullah Teaching Hospital Mansehra, Health Department KPK Author

DOI:

https://doi.org/10.2311/9tef6247

Keywords:

Pregnancy, Beyond expected date of delivery, Induction , Efficacy

Abstract

Introduction: Induction of labor (IOL) is a common practice that accounts for 20 % of all births. Different methods for IOL are practiced today, including vaginal tablets of dinoprostone, which is not yet studied in the current context. This study aims to assess the success rate of IOL with dinoprostone in women with beyond 36 weeks of pregnancy. Methods: This Descriptive cross-sectional study was conducted in the Department of Obstetrics & Gynecology, Ayub Teaching Hospital, Abbottabad, from 1st May 2023 to 31st October 2023. A total of 207 women with singleton pregnancy, gestational age ≥ 36 weeks, were included in the study. Tablet dinoprostone 3 mg was inserted in the posterior fornix vagina. Following application, the patient remained in a supine position for at least 15-30 minutes to prevent expulsion of the tablet. Cesarean delivery was performed in case of nonprogress of Labour. Data was analyzed with SPSS with a p-value of Chi-square test less than 0.05 was considered statistically significant. Results: A total of 178 patients with a mean age of 29.087±2.69 years, gestational age of 39.531±1.19 weeks participated in the study. The success rate was seen in 178 patients (86%) after Llabor induction in women beyond the expected delivery date. Conclusion: The effect of dinoprostone on the induction of Labour is promising. The optimal timing of offering induction of Labour to women with beyond 36 weeks of pregnancy warrants further investigation, as does further exploration of the risk profiles of women and their values and preferences.

Downloads

Download data is not yet available.

Author Biographies

  • Komal Imtiaz, King Abdullah Teaching Hospital Mansehra, Health Department KPK

    MBBS, FCPS, Medical Officer, Department of Gynecology and Obstetrics

  • Qurat Ul Aim, King Abdullah Teaching Hospital Mansehra, Health Department KPK

    MBBS, FCPS, Medical Officer, Department of Gynecology and Obstetrics

  • Maria Nawaz, King Abdullah Teaching Hospital Mansehra, Health Department KPK

    MBBS, FCPS, Medical Officer, Department of Gynecology and Obstetrics

References

Gill P, Lende MN, Van Hook JW. Induction of Labor. [Updated 2023 20th February]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459264/

Angolile CM, Max BL, Mushemba J, Mashauri HL. Global increased cesarean section rates and public health implications: A call to action. Health Sci Rep. 2023 18th May;6(5):e1274. doi: 10.1002/hsr2.1274. PMID: 37216058; PMCID: PMC10196217.

Ethiraj G, Ramachandra AC, Rajan S. Induction of Labor and Risk for Emergency Cesarean

Section in Women at Term Pregnancy. J Clin Gynecol Obstet.2019;8(1):17-20

Sanchez-Ramos L, Levine LD, Sciscione AC, Adiar CD, Maunitz AM, McKinney JA et al. Methods for the induction of labor: efficacy and safety. American Journal of Obstetrics & Gynecology.2024;230(3):S669 - S695

Bouchghoul H, Zeino S, Houllier M, Senat MV. Cervical ripening by prostaglandin dinoprostone in patients with a previous cesarean section. J Gynecol Obstet Hum Reprod. 2020 Apr;49(4):101699. doi: 10.1016/j.jogoh.2020.101699. Epub 2020 1st February. PMID: 32018044.

Socha MW, Flis W, Pietrus M, Wartęga M. Results of Induction of Labor with Prostaglandins E1 and dinoprostone (The RIPE Study): A Real-World Data Analysis of Obstetrical Effectiveness and Clinical Outcomes of Pharmacological Induction of Labor with Vaginal Inserts. Pharmaceuticals (Basel). 2023 Jul 8;16(7):982. doi: 10.3390/ph16070982. PMID: 37513894; PMCID: PMC10384291.

Torloni MR, Siaulys M, Riera R, Martimbianco ALC, Pacheco RL, Latorraca COC, Widmer M, Betran AP. Route of oxytocin administration for preventing blood loss at caesarean section: a systematic review with meta-analysis. BMJ Open. 2021 Sep 16;11(9):e051793. doi: 10.1136/bmjopen-2021-051793. PMID: 34531222; PMCID: PMC8449971.

Gabor Huszar. Biochemical Basis of Cervical Maturation;in Alan M. Golichowski, Physiology & Biochemistry Of Uterus In Pregnancy & Labor.1986 CRC Press.261. https://doi.org/10.1201/9780429282669

Madhavi KN, Polaiah KP, Sivaiah T. A comparative study of the safety and efficacy of intra vaginal misoprostol tablet versus intra cervical dinoprostone gel for cervical ripening and induction of Labour. J Evol Med Dent Sci. 2015;4(11):1769-75.

Rana F, Majeed S. Intracervical dinoprostone gel for cervical ripening and induction of Labour. Pak J Med Sci.2008;24(2):241-45

Khan QM, Mastoor K, Javaid A, Raza T, Ilyas S, Anjum S. The Comparison Of The Success Rates Of The Prostaglandin dinoprostone (dinoprostone) Versus Foley Catheter In Females With Postdate Pregnancy. JRMC. 2025 Jan. 1;28(4). 634-638. https://doi.org/10.37939/jrmc.v28i4.2605.

Thomas J, Fairclough A, Kavanagh J, Kelly AJ. Vaginal Prostaglandin (dinoprostone and PGF2a) for induction of Labour at term. Cochrane Database Syst Rev. 2014 19th June;2014(6):CD003101. doi: 10.1002/14651858.CD003101.pub3. PMID: 24941907; PMCID: PMC7138281.

Gunay T, Hocaoglu M. Factors Affecting the Success of Vaginal Prostaglandin dinoprostone Used for Labour Induction in Term Pregnants. Namık Kemal Tıp Dergisi 2019; 7(3): 245 - 252

Wennerholm UB, Hagberg H, Brorsson B, Bergh C. Induction of Labour versus expectant management for postdate pregnancy: Is there sufficient evidence for a change in clinical practice? Acta Obstet Gynecol Scand 2009; 88:6-17.

Caughey AB, Sundaram V, Kaimal AJ, Cheng YW, Gienger A, Little SE, et al. Maternal and neonatal outcomes of elective induction of Labour. Evidence reports / technical assessments. rockville (MD): Agency for Healthcare Research and Quality (US); 2009.

Caughey AB, Sundaram V, Kaimal AJ, Gienger A, Cheng YW, McDonald KM, et al. Systematic review: elective induction of Labour versus expectant management of pregnancy. Ann Intern Med 2009; 151:252-63, W53-63.

Laughon SK, Zhang J, Troendle J, Sun L, Reddy UM. Using a simplified Bishop score to predict vaginal delivery. Obstet Gynecol 2011; 117:805-11.

O'Brien JM, Mercer BM, Cleary NT, Sibai BM. Efficacy of outpatient induction with low-dose intravaginal prostaglandin dinoprostone: a randomized, double-blind, placebo controlled trial. Am J Obstet Gynecol 1995; 173:1855-9.

Sawai SK, O'Brien WF, Mastrogiannis DS, Krammer J, Mastry MG, Porter GW. Patient-administered outpatient intravaginal prostaglandin dinoprostone suppositories in postdate pregnancies: a doubleblind, randomized, placebocontrolled study. Obstet Gynecol 1994; 84:807-10.

Published

04/27/2025

Issue

Vol. 1 No. 1 (2025): The Genesis of MedPulse: Pioneering Research and Clinical Excellence

Section

Original Articles

License

Copyright (c) 2025 MedPulse Spectrum

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

  1. Grant of License: By submitting content (including but not limited to articles, manuscripts, and multimedia) to MedPulse Spectrum Journal, you grant us a non-exclusive, worldwide, royalty-free license to reproduce, distribute, publicly display, and perform the submitted content for the purpose of publishing, promoting, and improving the Journal.

  2. Copyright Ownership: Authors retain the copyright to their work published in MedPulse Spectrum Journal. We request, however, an exclusive license to be the first to publish the work, after which the authors are free to republish, reproduce, or distribute their content with proper acknowledgment of its initial publication in MedPulse Spectrum Journal.

  3. Attribution: Authors agree that their submitted content will be appropriately attributed to them in connection with its use by MedPulse Spectrum Journal.

  4. Permissions: Authors are responsible for obtaining any necessary permissions for the use of third-party materials included in their submissions and must provide evidence of such permissions upon request.

  5. Modification and Removal: MedPulse Spectrum Journal reserves the right to make necessary editorial modifications to submitted content for clarity, consistency, and adherence to journal standards. Authors can request content removal, subject to the Journal's discretion, recognizing that previous versions may persist in the Journal's archives.

  6. Non-Commercial Use: The use of content from MedPulse Spectrum Journal is intended for non-commercial purposes. Any commercial use requires explicit written permission from the Journal.

By submitting content to MedPulse Spectrum Journal, you acknowledge and agree to these licensing terms. The Journal reserves the right to update these terms periodically.

How to Cite

SUCCESSFUL INDUCTION OF LABOUR WITH DINOPROSTONE IN BEYOND 36 WEEKS OF  PREGNANCIES: AN OBSERVATIONAL STUDY: Induction of labour with dinoprostone. (2025). MedPulse Spectrum, 1(1). https://doi.org/10.2311/9tef6247